Clinical Trials

Cardiovascular Medicine Clinical Trials

• ACCELERATE: Assessment of clinical effects of cholesteryl ester transfer protein inhibition with  in patients at a high-risk for vascular outcomes. (PI: Lawrence Gimple)

• CAP2: Continued access to PREVAIL-CAP2 – Watchman device in left atrial appendage for stroke prevention in AFIB patients. (PI: Scott Lim)

• COAPT: Clinical outcomes assessment of the MitraClip percutaneous therapy for high surgical risk patients in functional mitral regurgitation patients. (PI: Scott Lim)

• EXCEL: Evaluation of XIENCE PRIME™ or XIENCE V® versus coronary artery bypass surgery for effectiveness of left main revascularization. (PI: Michael Ragosta)

• Exercise Capacity: Predictors of exercise capacity during stress exercise electrocardiography. (PI: Jamie Bourque, with Kevin Driver)

• EXERRT (Astellas): Exercise to Regadenoson in Recovery Trial(2013) PI: Jamie Bourque

• GLORIA: Global registry on long-term oral anti-thrombotic treatment in patients with atrial fibrillation. (PI: Allan Simpson)

• GORE-ASD: A study to evaluate safety and efficacy in the treatment of transcatheter closure of ostium secundum atrial septal defects using Gore septal occluder. Pediatric and adult patients. (PI: Scott Lim)

• GORE REDUCE: Gore Helex Septal Occluder and antiplatelet medical management for reduction of recurrent stroke or imaging-confirmed TIA in patients with patent foramen ovale (PFO). (PI: Nina Solenski)

• Lantheus 302: Assessment of myocardial perfusion using positron emission tomography (PET) imaging or flurpiridaz f18 injection in patients with known or suspected coronary heart disease (2013) (PI: Jamie Bourque)

• MRI-CT: Prevalence and correlation of abnormal flow reserve by stress CMR and non-obstructive CAD by cardiac CT in symptomatic diabetics: what is the optimal risk satisfaction method? (PI: Jamie Bourque)

• Pegasus: A randomized, double-blind, placebo-controlled, parallel group, multinational trial to assess the prevention of thrombotic events with ticagrelor compared to placebo on a background of acetyl salicylic acid (ASA) therapy in patients with history of myocardial infarction. (PI: Lawrence Gimple)

• PET-LVH: Noninvasive detection of early metabolic remodeling in left ventricular hypertrophy. (PI: Jamie Bourque)

• PreSERVE AMI: A prospective randomized double-blinded, placebo-controlled phase II trial of intra-coronary infusion of AMR001, a bone marrow-derived autologous CD34+ selected cell product in patients with acute myocardial infarction and low LVEF post STEMI. (PI: Michael Ragosta)

• REALISM: A continued access registry of the Evalve MitraClip system – EVEREST II real-world expanded multicenter study of the MitraClip system . Patients with severe degenerative or functional mitral insufficiency undergo Mitral Clip implantation. (PI: Scott Lim)

• Resolute Integrity: A post-approval study of the Medtronic Resolute Integrity Zotarolimus-Eluting Coronary Stent System in the treatment of de novo lesions in native coronary arteries with a reference vessel diameter of 2.25mm to 4.2mm. (PI: Michael Ragosta)