Grants and Awards

Division of Infectious Diseases

GRANTS AND AWARDS, FY 2014

Rebecca Dillingham, PI or co-PI:

NIH Office of Disease Prevention – 1D43TW009359-01: Water and Health in Limpopo [South Africa] Innovations Fellowship Program (Co-director, R. Guerrant; project partner, University of Venda)
National Science Foundation – EEC-1156999: “Research Experiences for Undergraduates” [REU] Site: Water, Society, and Health. (James Smith, PI; R. Dillingham, co-Investigator)
NIH Career Development (K) Award – 5K23AI077339-05: Enteroaggregative Escherichia coli (EAEC) infection in HIV-infected patients in Haiti
AIDS United; M A C AIDS: Positive Links: Smart Phones and Support for Successful Linkage to HIV Care in Rural Virginia (2 grant sources)

Joshua Eby, PI:

NIH/NIAID – 5K08AI081900: Bordetella adenylate cyclase toxin: the role of cell interaction in toxin function

Carol Gilchrist, PI:

NIH R21 parasitology grant (“Development of an Entamoeba histolytica Genotyping System”)

Richard Guerrant, PI:

Bill & Melinda Gates Foundation – OPP1066140: Novel Metabonomic Biomarkers of Gut Function and Health: Modeling Enteropathy (EE) and Field Validation
Foundation for the National Institutes of Health – Grand Challenges in Global: Gates Malnutrition & Enteric Disease program
NIH/John E. Fogarty International Center – 1D43TW009359: Global Infectious Disease Research Training Program – The Water and Health in Limpopo Innovations Fellowship Program
NIH/John E. Fogarty International Center – 5D43TW006578-10: Global Infectious Disease Research Training Program: UVA-Brazil (Partner institution – Federal University of Ceara, Fortaleza, Brazil)
NIH/NIAID – 5U01AI026512-22: Long term Impact and Intervention for Diarrhea in Brazil
University Of Maryland – SR00001830: New Therapeutics for Shiga Toxin-E. Coli Disease
NIH/NIAID – 5U01AI075526-05: Tailoring Novel Therapeutics for Emerging Drug-Resistant C. Difficile Colitis

Erik Hewlett, PI:

NIH/NIAID – 5R01AI018000-31: Bordetella Cyclase Toxin – Effect on Leukocytes and Respiratory Epithelial Cells
University Of Maryland (various SR0000): MARCE2 Mid-Atlantic Regional Center of Excellence in Biodefense
List Biological Laboratories, Inc.: Research Funding Agreement Between UVA & List Biological Laboratories
U.S. Department of Defense/Army Research Office – W911NF-12-1-0599: Identifying a path Towards Rapid Discrimination o f Natural , Accidental and Deliberate Infection Disease Outbreaks (Co-investigator-Stephen Turner)

Scott Heysell, PI:

NIH-NIAID – 5K23AI099019: Mentored Clinical Scientist Development Award – Clinical impact of anti-TB drug levels and M. tuberculosis susceptibility
NIH R21: MDR TB treatment

Paul Hoffman, PI:

NIH R21/33, development of the new antibiotic Amixicile

Eric Houpt, PI:

Bill & Melinda Gates Foundation – OPP1019093: Next Generation Molecular Diagnostic Technologies for Developing Countries (to further develop and deploy molecular diagnostics for diarrheal diseases to global surveillance studies)
NIH/John E. Fogarty International Center – 5D43TW008270-04: Global Infectious Disease Research Training Program – UVA-Tanzania ID Training program (co-PI: Gibson Kibiki, Kilimanjaro Clinical Research Institute/Kilimanjaro Christian Medical Centre, Moshi, Tanzania)
NIH/NIAID – 5R01AI093358-03: Tuberculosis Second Line Drug Susceptibility Chip
NIH/NIAID – 5U01AI075396-05: Comprehensive Molecular Diagnosis for Food and Waterborne Enteropathogens
Imperial College London – PO-2962557: London Polio
CDC Foundation/Bill and Melinda Gates Foundation (subcontract): “Leveraging rotavirus networks” [deploying diarrheal disease TaqMan Array cards to three World Health Organization laboratories to document rotavirus epidemiology and the role of other enteropathogens]
(Co-PI, Jie Liu): NIH, Gates and CDC support for next-generation diagnostics for TB and enterics: “Next Generation Molecular Diagnostics for Developing Countries” funded by the Bill and Melinda Gates Foundation (Oct. 2013 – Oct. 2015). Will further develop and deploy molecular diagnostics for diarrheal diseases to global surveillance studies.

Molly Hughes, PI:

NIH/NIAID – 1R01AI099097-01A1: Bacillus anthracis targets involved in chemokine-mediated antimicrobial activity
Commonwealth Health Research Board – 207-03-11: Development of Novel Antimicrobial Agents for Multi-Drug Resistant Bacterial Pathogens

Barbara Mann, PI:

NIH/NIAID – 1R56AI091746-01: Mechanisms of Francisella Virulence
University of Maryland, Baltimore – 7762/SR00002668: Advancement of a Defined, Protective Tularemia Vaccine

William A. Petri, Jr., PI:

NIH/NIAID – 5T32AI055432-10: Biodefense Research Training and Career Development
NIH/NIAID – 5T32AI007046-35: Infectious Diseases Training Program
NIH/NIAID – 5R01AI026649-24: Role of Leptin in Innate Mucosal Defense from Amebiasis
NIH/NIAID – 5R01AI043596-14: Field Studies of Human Immunity to Amebiasis in Bangladesh
U.S. National Center For Research Resources – 1S10RR029375-01: Flow Cytometry for BSL 3
U.S. Department of Defense, Defense Threat Reduction Agency – HDTRA1-10-1-0082: Characterize Respiratory Pathogenes Endemic to Pakistan
Bill & Melinda Gates Foundation – OPP1017093: Exploration of the Biologic Basis for Underperformance of OPV and Rotavirus Vaccines in Bangladesh and India
Bill & Melinda Gates Foundation – OPP1066629: Quik Chek Rapid Immunity Assessment Test
Bill & Melinda Gates Foundation – BMGF 51635: Study of Risk Factors for Malnutrition Using Molecular & Genomic Tools
Bill and Melinda Gates Foundation – Production of a Reg1B Fecal Enzyme Immunoassay as a Potential Biomarker of Childhood Stunting (development and testing of a biomarker of intestinal epithelial cell health as a predictor of the development of malnutrition in children)
Techlab Research – 1 R43 AI085938-01A1: Alum-absorbed subunit vaccine to prevent intestinal amebiasis
Techlab Research – 1 R41AI094733-01A1: Point-of-Care Test for Entamoeba histolytica Cysts
Life Sciences Research Foundation – LSRF-K 72542: The Life Sciences Research Foundation Postdoctoral Research Fellowship (Ralston)
University Of Maryland – SR00002327: Multi-Center Severe Diarrheal Disease Burden & Etiology Study
The Hartwell Foundation/Hartwell Fellowship: New therapeutics for ameobiasis in children (Ralston)
University of Washington – 749864: Accelerated Molecular Probe Pipeline UW

Amy Mather, PI:

Identification of transmission patterns of antibiotic-resistant gram negative bacteria; UVA-Oxford collaboration on molecular epidemiology of carbapenemase-producing Enterobacteriacea

Christopher Moore, PI:

Henry Rose Carter Research Award, “Prevalence of non-Plasmodium falciparum malaria in Uganda” (provides support for innovative research related to malaria or other public health problems)

Tania Thomas, PI:

NIH NIAID – 5K23AI097197-02: Mentored Clinical Scientist Development Award – Improving Pediatric TB Diagnosis and Management in Tanzania

Gregory Townsend, PI:

James Madison University – V12-313-05 & V11-287-04: JMU Part B Ryan White Medical Case Management Services; Treatment Adherence and Case Management Services
U.S. Health Resources & Services Administration:
- 5 H76HA04385-09: HIV Early Intervention Services (EIS) Program
- 1H12HA24864-01-0: Ryan White Title IV Women, Infants, Children, Youth and Affected Family Members AIDS Healthcare
- 1 H97HA25002-01: HRSA HIT Capacity Building FY12-13
- H76HA04385A0: Title III Ryan White HIV Clinical Care Grant
Virginia Department of Health – 601-611-45416-08-HIV & UVA-RWB611AU45416-1: Ryan White Financial Eligibility Screening

Cirle Warren, PI:

Gates Grand Challenges grant to study 3-D cell culture models of the gut

Wen Yuan, PI:

NIH-NIAID – 5R33AI081616-04: Functional HIV Envelope Trimer as a Prophylactic HIV/AIDS Vaccine Candidate
NIH-NIAID – 5R21AI087502-02: An HIV Vaccine Candidate Targeting the Coreceptor Binding Site

NIAID = National Institute of Allergy and Infectious Diseases

ID Graduate Students/Postdocs/Fellows:

2013 American Society of Tropical Medicine and Hygiene Travel award [to attend & present at ASTMH annual meeting] (graduate students/faculty mentor):
- Maria Auma/Chris Moore: role of malaria in adult sepsis in Mbarara, Uganda
- Nona Jiang/Bill Petri: role of inflammation in poor infant development in Bangladesh
2014 Amnis Travel Stipend: Katy Ralston/Bill Petri: trogocytosis-like ingestion in Entamoeba histolytica
American Society for Microbiology (ASM) Robert D. Watkins Graduate Research Fellowship (3-year grant): Zegbeh Kpadeh (mentor: Paul Hoffman)