News from the Mehrad Lab

Division of Pulmonary & Critical Care Medicine
RESEARCH: News from the Mehrad Lab

Division of Pulmonary Medicine’s Borna Mehrad, MBBS, the E. Cato Drash Professor of Pulmonary Medicine, has new grants, publications and a patent to report from his lab.

Grants

• National Institutes of Health (R21AI117397). “Neutrophils and adaptive immunity against invasive aspergillosis.” Borna Mehrad, PI; annual direct costs $137,500 (4/1/15–3/31/17).
• University of Virginia Department of Medicine Transformative, Collaborative Science Pilot Grant. “Hyper-polarized xenon MRI as a biomarker in pulmonary fibrosis.” Borna Mehrad, Co-PI; annual direct cost, $95,000 (1/1/15–12/31/15).

Publications

• Choi YH, Burdick MD, Strieter BA, Mehrad B, Strieter RM. CXCR4, but not CXCR7, discriminates metastatic behavior in non-small cell lung cancer cells. Molecular Cancer Research: MCR. 2014;12(1):38-47. doi: 10.1158/1541-7786.MCR-12-0334.
• Jones RM, Enfield KB, Mehrad B, Keeley EC. Prevalence of obstructive coronary artery disease in patients undergoing lung transplantation: case series and review of the literature. Catheterization & Cardiovascular Interventions. 2014;84(1):1-6. doi: 10.1002/ccd.25261.
• Karafin MS, Dogra S, Rodeghier M, Burdick M, Mehrad B, Rose CE, Strieter RM, DeBaun MR, Strunk RC, Field JJ. Increased circulating fibrocytes are associated with higher reticulocyte percent in children with sickle cell anemia. Pediatric Pulmonology. 2015 Jun 30. doi: 10.1002/ppul.23248. [Epub ahead of print]
• Trimble A, Gochuico BR, Markello TC, Fischer R, Gahl WA, Lee JK, Kim Y, Burdick MD, Strieter RM, Mehrad B. Circulating fibrocytes as biomarker of prognosis in Hermansky-Pudlak syndrome. American Journal of Respiratory & Critical Care Medicine. 2014 Dec 15;190(12):1395-401. doi: 10.1164/rccm.201407-1287OC.s.
• Mehrad B, Clark NM, Zhanel GG, Lynch JP 3rd. Antimicrobial resistance in hospital-acquired gram-negative bacterial infections. Chest. 2015 May;147(5):1413-21. doi: 10.1378/chest.14-2171.

 Patent

• “Compositions and Methods Useful as Antimicrobial Agents.” United States Provisional Patent Application Serial No. 61/894,484, filed 10/23/13; International Patent Application Serial No. PCT/US2014/061583, filed 10/21/14.